Our Solution

We are developing a medical device that will enhance drug delivery to brain diseases by reversibly opening up the blood-brain barrier (BBB) in a simple, painless, patient-friendly 30 minute visit.

Our Product

graphic of steps used by device to open the BBB
The Cordance medical device process for opening the BBB.
  • The patient is fitted with the Cordance cap.
  • Utilizing real-time transcranial imaging and a pre-acquired MRI, the location of the Cordance cap is calculated in relation to the patient’s brain anatomy.
  • The patient receives an infusion of microbubbles (pressurized bubbles of inert gas).
  • The low-frequency ultrasound array beam forms to the region of interest.
  • At the beam formed location, the microbubbles oscillate in size and shape putting mechanical pressure on the BBB, and open the BBB for 4-24 hours. The patient receives the systemic therapy (e.g. chemotherapy, antibody, immunotherapy, etc.) which has free access to brain tissue in the region of interest.

Product Features

  • Non-invasive and painless
  • Designed so that patient restraints or head shaving is not needed
  • Portable and designed for community
  • Designed to seamlessly fit into commonly used work-flows in infusion treatment centers