We are developing a medical device that will enhance drug delivery to brain diseases by reversibly opening up the blood-brain barrier (BBB) in a simple, painless, patient-friendly 30 minute visit.
Our Product

- The patient is fitted with the Cordance cap
- Utilizing real-time transcranial imaging and a pre-acquired MRI, the location of the Cordance cap is calculated in relation to the patient’s brain anatomy
- The patient receives an infusion of microbubbles (pressurized bubbles of inert gas)
- The low-frequency ultrasound array beam forms to the region of interest
- At the beam formed location, the microbubbles oscillate in size and shape putting mechanical pressure on the BBB, and open the BBB for 4-24 hours
- The patient receives the systemic therapy (e.g. chemotherapy, antibody, immunotherapy, etc.) which has free access to brain tissue in the region of interest
Product Features
- Non-invasive and painless
- Designed so that patient restraints or head shaving is not needed
- Portable and designed for community
- Designed to seamlessly fit into commonly used work-flows in infusion treatment centers