Focused Ultrasound has been utilized to increase the blood-brain barrier penetrance to multiple classes of drugs. Below are references to different studies demonstrating efficacy of drug delivery:
- Chemotherapies: Temozolomide, Irinotecan, Doxorubicin, Methotrexate, Carboplatin, Paclitaxel
- Antibodies: Trastuzumab, anti PD-1 antibody, anti-amyloid-beta (Aβ) antibodies, dopamine receptor antibodies
- Angiogenesis Inhibitors: Bevacizumab
- Gene Therapy: HTT- siRNA, viruses
- Cell Therapy: Stem cells, CAR-T
- Nanoparticles